Oligos
Synthesis Scales
(Expected yields for an unmodified 20mer)
|
Scale |
OD Units |
Mass |
|
50 nanomole |
>5 ODs |
150 micrograms |
|
0.2 micromole |
>10 ODs |
300-400 micrograms |
|
1 micromole |
>50 ODs |
1.8 - 2.5 mg |
|
10 micromole |
>425 ODs |
14 - 18 mg |
|
50 µmole, or larger |
Inquire |
Inquire |
Because of our high coupling efficiencies, our overall yields at a given scale are relatively high. The percentage full-length product is also exceptionally high.
Backbone Chemistries
|
Backbone |
Nuclease Stability |
Hybrid Stability |
|
DNA |
Unstable |
Stable |
|
|
|
|
|
Phosphorothioate DNA |
Stable |
Moderately Stable |
|
RNA |
Highly Unstable |
Very Stable |
|
Phosphorothioate RNA |
Moderately Stable |
Stable |
|
2'-O-Methyl RNA |
Stable to Endo, Unstable to Exo |
Very Stable |
|
Phosphorothioate 2'-O-Me RNA |
Highly Stable |
Stable |
|
P-Ethoxy DNA |
Stable |
Stable |
|
P-Ethoxy 2'-O-Me RNA |
Stable |
Stable |
|
CHIMERICS |
N/A |
N/A |