Oligos

Synthesis Scales

(Expected yields for an unmodified 20mer)

Scale

OD Units

Mass

50 nanomole

>5 ODs

150 micrograms

0.2 micromole

>10 ODs

300-400 micrograms

1 micromole

>50 ODs

1.8 - 2.5 mg

10 micromole

>425 ODs

14 - 18 mg

50 µmole, or larger

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Because of our high coupling efficiencies, our overall yields at a given scale are relatively high. The percentage full-length product is also exceptionally high.

Backbone Chemistries

Backbone

Nuclease Stability

Hybrid Stability

DNA

Unstable

Stable

 

 

 

Phosphorothioate DNA

Stable

Moderately Stable

RNA

Highly Unstable

Very Stable

Phosphorothioate RNA

Moderately Stable

Stable

2'-O-Methyl RNA

Stable to Endo, Unstable to Exo

Very Stable

Phosphorothioate 2'-O-Me RNA

Highly Stable

Stable

P-Ethoxy DNA

Stable

Stable

P-Ethoxy 2'-O-Me RNA

Stable

Stable

CHIMERICS

N/A

N/A