|
Oligos
SYNTHESIS SCALES
(Expected yields for an unmodified 20mer)
Scale
|
OD Units
|
Mass
|
| 50 nanomole |
>5 ODs
|
150 micrograms
|
| 0.2 micromole |
>10 ODs
|
300-400 micrograms
|
| 1 micromole |
>50 ODs
|
1.8 - 2.5 mg
|
| 10 micromole (jumbo) |
>425 ODs
|
14 - 18 mg
|
| 50 um, 1 gm & larger |
Inquire
|
Inquire
|
Because of our high coupling efficiencies, our overall yields at a given scale
are relatively high. The percentage full-length product is also exceptionally
high.
BACKBONE CHEMISTRIES
Backbone
|
Nuclease Stability
|
Hybrid Stability
|
| DNA |
Unstable
|
Stable
|
| OPTIMIZED ANTISENSE |
Stable
|
Very Stable
|
| Phosphorothioate DNA |
Stable
|
Moderately Stable
|
| RNA |
Highly Unstable
|
Very Stable
|
| Phosphorothioate RNA |
Moderately Stable
|
Stable
|
| 2'-O-Methyl RNA |
Stable
to Endo, Unstable to Exo
|
Very Stable
|
| Phosphorothioate 2'-O-Mt RNA |
Highly Stable
|
Stable
|
| P-Ethoxy DNA |
Stable
|
Stable
|
| P-Ethoxy 2'-O-Mt RNA |
Stable
|
Stable
|
| CHIMERICS |
N/A
|
N/A
|
|
